The major lipid disorders (lipidoses) are ones in which plasma lipid levels are abnormal, as in hyperlipidaemia, hypercholesterolaemia and chylomicron retention disease. See also apolipoprotein B; LDL receptor. Abnormal accumulations of lipids in tissues (lipidoses) can occur in lysosomal storage diseases (e.g. Gaucher's, Krabbe's, Tay–Sachs, Niemann–Pick diseases) or where there are defects in enzymes involved in lipid metabolism (cerebrotendinous xanthomatosis). High levels of cholesterol are a risk factor for atherosclerosis. See also Anderson's disease; sitosterolaemia; hypercholanaemia. More subtle defects in lipids may affect the behaviour of receptors or ion channels that are embedded in a phospholipid bilayer and are sensitive to its physical properties. Whether obesity is a lipid disorder is questionable (but see adipokine).
Subjects: Medicine and Health.