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Lis1


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The product (platelet-activating factor acetylhydrolase IB subunit α, 410 aa) of a gene that is deleted or mutated in patients with lissencephaly. It interacts with nuclear distribution gene E homologue-like 1 and is essential for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons.

Subjects: Medicine and Health.


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