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lipoma-preferred partner


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A protein (LIM domain-containing preferred translocation partner in lipoma, LPP, 612 aa) with considerable homology to zyxin and containing three LIM domains. It is involved in the translocation t(3;12) in benign lipomas in which the LPP gene from chromosome 3 becomes fused to the DNA-binding molecule HMGIC (high mobility group 1C). It can also become fused to the mixed lineage leukaemia gene on chromosome 11.

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