Littleton was born at Stoke St Milborough, Shropshire, in 1625, and died some time after 1695, probably in London. His father was a baronet and landowner, and there was probably a family connection with Sir Edward Littleton (d. 1707), prominent in the affairs of the East India Company around the same time. Littleton was educated at Westminster School and St Mary Hall, Oxford, graduating BA in 1644 and MA in 1648; he was elected a fellow of All Souls, Oxford in 1647, and was made Senior proctor of the university in 1656. In 1664 he was called to the bar, and two years later took up an appointment as secretary to Lord Willoughby of Parham, king's attorney for Barbados. Littleton spent the years 1666–83 on Barbados, becoming a judge in 1670. He also married a local heiress in 1669 and became a considerable landowner on the island.
From The Biographical Dictionary of British Economists in Oxford Reference.