Ligand-activated transcription factors (LXRα and LXRβ), belonging to nuclear receptor family-1, that induce genes involved in cholesterol homeostasis and in lipogenesis, through their interaction with specific, naturally occurring oxysterols. They are expressed in liver, intestine, and adrenal gland, and can complex with retinoid-X receptor (RXR). LXRA specifically interacts with RXRA to form a functional heterodimer in which RXRA is the ligand-binding subunit and transcription is activated by retinoids. In experimental animals elimination of LXR activity mimics many aspects of Tangier disease.
Subjects: Medicine and Health.