Overview

liver disorders


'liver disorders' can also refer to...

liver disorders

Liver disorders

Gastrointestinal and liver disorders

Liver disorder and the HFE locus

Cardiovascular, Metabolic, Liver, Kidney, and Inflammatory Disorders

Cell-based therapeutics for liver disorders

Miscellaneous disorders of the bowel and liver

Digestive Diseases and Disorders of the Pancreas and Liver

Congenital disorders of the liver, biliary tract, and pancreas

Non-alcoholic fatty liver: a common manifestation of a metabolic disorder

Fulminant post-transplant lymphoproliferative disorder presenting with lactic acidosis and acute liver failure

PT556. A Case Report of Atomoxetine Related Liver Injury in A Child with Attention Deficit/Hyperactivity Disorder, Autistic Spectrum Disorder and Epilepsy

Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-lpr/lpr mice

The Effect of Cigarette Smoke Exposure and Ascorbic Acid Intake on Gene Expression of Antioxidant Enzymes and Other Related Enzymes in the Livers and Lungs of Shionogi Rats with Osteogenic Disorders

In vivo effects of ascorbate and glutathione on the uptake of chromium, formation of chromium(V), chromium–DNA binding and 8-hydroxy-2′-deoxyguanosine in liver and kidney of Osteogenic Disorder Shionogi rats following treatment with chromium(VI)

HAY, John (1873 - 1959), retired; late Professor of Medicine, Liverpool University, now Professor Emeritus; Consulting Hon. Physician, Liverpool Royal Infirmary; Regional Adviser in Medicine, Ministry of Health; Gas Expert to Ministry of Health; Honorary member of Cardiac Society of Great Britain and Ireland; late Visiting Physician, City Hospital, Walton; late Senior Medical Officer, Royal Insurance Co.; Ex-Pres. Microscopical Society; Ex-President, Liverpool Medical Institution; Ex-President, Liver Sketching Club; Consulting Physician, Victoria Central Hospital, Wallasey, Liverpool Maternity Hospital, the Children’s Convalescent Home, West Kirby, the County Hospital, Kendal; Lieut-Colonel RAMC (T), Hon. consulting Physician to Ministry of Pensions in Cardiovascular cases in the North-Western region; late Specialist in Cardiac Disorders, Western Command

 

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The liver is the major site of many basic metabolic functions and the cells (hepatocytes) appear relatively unspecialized, the archetypal animal cell of textbooks. Liver is one of the few human tissues to have some capacity to regenerate (see oval cells). Not only does the liver produce many of the plasma proteins but it is an important site for detoxification of drugs and other xenobiotics (see cytochrome P450; glutathione S transferases) and a major site of glycogen storage. Glycogen storage diseases have a serious impact on the function of liver and many other tissues (see also phosphorylase kinase). Kuppfer cells are important for removal of particles and effete erythrocytes from the circulation. Inflammation of the liver (hepatitis) can be caused by various viruses, and hepatitis B and C virus infection is a major risk factor for hepatocarcinoma. Chronic inflammation, often a result of excess alcohol intake, can lead to cirrhosis and fibrosis (see Ito cells). Markers of liver dysfunction include alanine aminotransferase and formiminotransferase-cyclodeaminase. Accumulation of various substances in the liver can also lead to cirrhosis (e.g. in haemochromatosis and Wilson's disease) and lipid accumulation in lipocytes can be a feature of dietary overload (as in production of foie gras). There are various disorders of the bile system, including Alagille's syndrome, primary sclerosing cholangitis, and Gilbert's syndrome. Some toxins (e.g. aflatoxins) particularly affect the liver. See Torres body.

Subjects: Medicine and Health.


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