locus control region

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'locus control region' can also refer to...

locus control region

locus control region

β‐Globin locus control region HS2 and HS3 interact structurally and functionally

Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity

Activation of the β-like globin genes in transgenic mice is dependent on the presence of the β-locus control region

Formation of a large, complex domain of histone hyperacetylation at human 14q32.1 requires the serpin locus control region

Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster

Requirements for utilization of CREB binding protein by hypersensitive site two of the β-globin locus control region

The human growth hormone locus control region mediates long-distance transcriptional activation independent of nuclear matrix attachment regions

Evidence that DNase I hypersensitive site 5 of the human β-globin locus control region functions as a chromosomal insulator in transgenic mice

Nucleosome and transcription activator antagonism at human β-globin locus control region DNase I hypersensitive sites

Structural polymorphism exhibited by a quasipalindrome present in the locus control region (LCR) of the human β-globin gene cluster

Protein—DNA interactions in the human β-globin locus control region hypersensitive site-2 as revealed by four nitrogen mustards

Hairpin–duplex equilibrium reflected in the A→B transition in an undecamer quasi‐palindrome present in the locus control region of the human β‐globin gene cluster

Sequences Within and Flanking Hypersensitive Sites 3 and 2 of the β-Globin Locus Control Region Required for Synergistic Versus Additive Interaction With the ε-globin Gene Promoter

Conserved elements containing NF-E2 and tandem GATA binding sites are required for erythroid-specific chromatin structure reorganization within the human β-globin locus control region


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The nontranscribed region that contains the promoters and enhancers which regulate the expression of a particular gene. Often taken to be a single region 0–2 kb upstream of the transcriptional start site.

Subjects: Chemistry — Medicine and Health.

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