Lyon hypothesis

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The hypothesis that gene dosage imbalance between males and females, because of the presence of two X chromosomes in females (XX) as opposed to only one in males (XY), is compensated for by random inactivation of one of the X chromosomes in the somatic cells of females. The inactivated X chromosome becomes the Barr body (see sex chromatin). M. F. Lyon (1925), British geneticist

Subjects: Medicine and Health — Science and Mathematics.

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