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lysophosphatidic acid


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lysophosphatidic acid

lysophosphatidic acid

Lysophosphatidic Acid Receptors Determine Tumorigenicity and Aggressiveness of Ovarian Cancer Cells

Dual Mechanisms for Lysophosphatidic Acid Stimulation of Human Ovarian Carcinoma Cells

Malignant effusions contain lysophosphatidic acid (LPA)-like activity

Lysophosphatidic acid as a lipid mediator with multiple biological actions

Addition of lysophosphatidic acid to mouse oocyte maturation media can enhance fertilization and developmental competence

A New Link in Ovarian Cancer Angiogenesis: Lysophosphatidic Acid and Vascular Endothelial Growth Factor Expression

Lysophosphatidic Acid Induction of Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

Loss of Plastidic Lysophosphatidic Acid Acyltransferase Causes Embryo-Lethality in Arabidopsis

Lysophosphatidic acid-activated Cl− current activity in human systemic sclerosis skin fibroblasts

Lysophospholipase D activity exists in the urine to catalyse the formation of lysophosphatidic acid

Lysophosphatidic acid inhibits the cytotoxic activity of NK cells: involvement of Gs protein-mediated signaling

Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood

Altered activity of lysophospholipase D, which produces bioactive lysophosphatidic acid and choline, in serum from women with pathological pregnancy

Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells

LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites

Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes

Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo

 

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(LPA, lysoPA)

A phospholipid derivative with a single acyl chain, produced by a lysophospholipase D (autotaxin), that has pleiotropic signalling activity causing mitogenesis, cell survival, inhibition of adenylyl cyclase, and calcium mobilization. It will also induce platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumour cell invasion. The lysophosphatidic acid receptor-1 (LPAR 1, endothelial differentiation gene 2, EDG2; 364 aa), is a G-protein-coupled receptor through which most of its activities are mediated; the receptor also binds sphingosine 1-phosphate. LPAR1 is also reported to be expressed in the nucleus and to traffic between plasma membrane and nucleus in response to LPA. There are related receptors, LPAR2 (EDG4) and LPAR3 (EDG7). LPAR4 is a member of the purinergic GPCR cluster.

Subjects: Medicine and Health.


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