Heavily glycosylated proteins of lysosomal and plasma membranes (lysosomal-associated membrane glycoproteins), between 90 and 140 kDa depending on the extent of glycosylation. They may protect membrane from attack by lysosomal enzymes and regulate fusion of lysosomes with primary autophagocytic vacuoles. LAMP-1 is also known as LEP100 (lysosomes, endosomes and plasma membrane, 100 kDa) and LGP120. Defects in LAMP-2 cause Danon's disease.
Subjects: Chemistry — Medicine and Health.