A homodimeric glycoprotein (macrophage colony-stimulating factor, CSF-1) that plays an important role in stimulating the growth of colonies of macrophages and granulocytes and the growth, survival, and differentiation of monocytes. Isoforms M-CSF-α (256 aa), M-CSF-β (554 aa), M-CSF-γ (438 aa) and CSF4 arise by alternative splicing. MCSF is important in adipocyte hyperplasia, in osteoclast differentiation, and in monocyte-to-macrophage differentiation in the arterial intima in atherosclerosis. The receptor for MCSF (c-fms) has a cytoplasmic tyrosine kinase domain and is expressed on the pluripotent precursor and mature osteoclasts and macrophages. Mutation in MCSF leads to osteopetrosis because of osteoclast deficiency.
Subjects: Medicine and Health.