Murine cytokines with closely related human homologues. MIP1 was originally identified as a murine cytokine with inflammatory and chemokinetic properties. Two peptides (69 aa) are responsible, MIP1-α (CCL3; SIS-α, L2G25B, SCYA3, TY5, endogenous pyrogen; identical to human 464.1) and MIP1-β (CCL4; SIS-γ; L2G25B; identical to human 744.1). Subsequently other related forms have been isolated: MIP1-γ (CCL9) and MIP1-δ (CCL15). The latter is chemotactic for T cells and monocytes, but not for neutrophils, eosinophils, or B cells. MIP2 (CXCL1, 6 kDa) is chemotactic for neutrophils. MIP3-α (CCL20; LARC, Exodus) and MIP3-β (CCL19) are CC-chemokines.
Subjects: Medicine and Health — Chemistry.