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madindolines


'madindolines' can also refer to...

 

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Noncytotoxic indole alkaloids originally isolated from a fermentation broth of Streptomyces nitrosporeus K93-0711. Madindoline A (MadA; MDL-A) binds competitively but noncovalently to the extracellular domain of the membrane glycoprotein gp130 and inhibits the homodimerization of the trimeric IL-6/IL-6R/gp130 or the IL-11/gp130 complex, thereby blocking activation of the JAK–STAT signal transduction pathway. Analogues of madindolines have been synthesized as potent IL-6 inhibitors.

Subjects: Medicine and Health.


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