Overview

MAD mutations


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Mitotic arrest deficient mutations. The wild-type alleles of these genes encode proteins that bind to kinetochores until spindle fibers attach to them. If there is a failure of spindle microtubules to attach, the MAD protein remains bound to the kinetochore, and the entry into anaphase is blocked. See checkpoints, mitosis.

Subjects: Genetics and Genomics.


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