A large family of transporters (MFSDs) with ten to twelve membrane-spanning domains found in bacteria, archaea, and eukaryotes that act as permeases for simple sugars, oligosaccharides, inositols, drugs, amino acids, nucleosides, organophosphate esters, tricarboxylic acid cycle metabolites, and various organic and inorganic anions and cations. Many families (at least eighteen) have been recognized. In humans they participate in various important physiological processes. MFSD2 is the receptor for syncytin-2; mutation in MFSD8 causes neuronal ceroid lipofuscinosis type 7.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=98904#id380115 A review of MFSDs.
Subjects: Medicine and Health.