mannose-6-phosphate receptor

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There are two unrelated receptors, both required for proper sorting of lysosomal enzymes. The cation-dependent mannose-6-phosphate receptor is a transmembrane protein of ~46 kDa and functions as a dimer. The cation-independent receptor (215 kDa) is identical to the receptor for insulin-like growth factor II (IGF2R) and has a role in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor β, and the degradation of IGF2, which is a growth factor that is often overproduced in tumours. It is also apparently the site to which granzyme B binds in T-cell killing.

Subjects: Chemistry.

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