A term coined by A. M. Olonikov for the formation of nucleic acid replicas that are shortened relative to their templates. Telomeres (q.v.) undergo marginotomy, and the maximum number of mitoses any somatic cell line can undergo is correlated with the lengths of their telomeres and the rate at which they shorten per replication. See Chronology, 1971, Olonikov; Hayflick limit.
Subjects: Genetics and Genomics.