A gene (mouse double minute) encoding Mdm2 (491 aa), a protein that binds to the transcriptional activator domain of the tumour suppressor p53 and targets it for destruction by the proteosome. Expression of Mdm is, however, activated by p53 so there is a feedback loop. Has a similar effect on the retinoblastoma gene product. A second protein, Mdm4 (490 aa), has similar properties.
Subjects: Medicine and Health — Chemistry.