[E. G. Melkersson (1898–1932), Swedish physician; C. Rosenthal (1892–1937), German neurologist] A rare neurological disorder characterized by recurring facial paralysis, swelling of the face and lips (usually the upper lip), enlargement of the glottis, and the development of enlargement (hypertrophy) of the tongue, together with folds and furrows. The onset is in childhood or early adolescence. The lips may become hard, cracked, and fissured with a reddish-brown discoloration. Some cases are associated with Crohn's disease and sarcoid. Treatment is symptomatic.