A development in genetic epidemiology based on Mendel's second law that inheritance of one trait is independent of inheritance of other traits. It uses common genetic polymorphisms that are known to influence exposure patterns (such as propensity to drink alcohol) or have effects equivalent to those produced by modifiable exposures (such as raised blood cholesterol concentration). Associations between genetic variants and outcome are not generally confounded by behavioral or environmental exposures. This means that observational studies of genetic variants have properties similar to intention to treat analyses in randomized controlled trials.
Subjects: Public Health and Epidemiology.