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merlin


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The protein product (schwannomin, neurofibromin 2, 587 aa) of the neurofibromatosis 2 (NF2) tumour suppressor gene, one of the ERM (ezrin–radixin–moesin) family of proteins that link the cytoskeleton to membrane proteins. Merlin is defective or absent in schwannomas and meningiomas and in most cases mutations in merlin result in loss of adhesion. The tumour suppressor function of merlin is blocked by phosphorylation and activated by protein phosphatase I (myosin phosphatase target subunit 1, MYPT1).

Subjects: Medicine and Health — Chemistry.


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