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mesangial cells


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Specialized cells found in the mammalian kidney. Extraglomerular mesangial cells (lacis cells) are found outside the glomerulus, and form the juxtaglomerular apparatus in combination with cells of the macula densa of the distal convoluted tubule and juxtaglomerular cells of the afferent arteriole. The juxtaglomerular apparatus controls blood pressure through the renin–angiotensin–aldosterone system. Intraglomerular mesangial cells are specialized pericytes, involved in filtration, structural support, and phagocytosis. They may also act as antigen-presenting accessory cells.

Subjects: Medicine and Health.


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