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An oncogene from a chemically transformed human osteosarcoma-derived cell line. The alpha subunit of the c-Met proto-oncogene product is extracellular, the beta subunit is the hepatocyte growth factor receptor, a tyrosine kinase. It is overexpressed in a significant percentage of human cancers, particularly renal and hepatocellular carcinomas.

Subjects: Chemistry — Medicine and Health.

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