methylcrotonyl-CoA carboxylase

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EC; an enzyme of the pathway for the degradation of leucine. It catalyses the formation of 3‐methylglutaconyl‐CoA from ATP, 3‐methylcrotonyl‐CoA, and HCO3 with release of ADP and orthophosphate. Biotin is a cofactor. The 3‐methylglutaconyl‐CoA is then converted to 3‐hydroxy‐3‐methylglutaryl‐CoA.


Subjects: Chemistry.

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