MHC class II protein

'MHC class II protein' can also refer to...

MHC class II protein

MHC class II protein

Protein kinase C delta stimulates antigen presentation by Class II MHC in murine dendritic cells

Allelic variations in rat MHC class II binding of myelin basic protein peptides correlate with encephalitogenicity

Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7.

Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules

Combinations of dominant-negative class II transactivator, p300 or CDK9 proteins block the expression of MHC II genes

MHC class II gene associations with autoantibodies to U1A and SmD1 proteins

CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes

Binding of copolymer 1 and myelin basic protein leads to clustering of class II MHC molecules on antigen-presenting cells.

MHC class II‐mediated apoptosis of mature dendritic cells proceeds by activation of the protein kinase C‐δ isoenzyme

Activation of T cells by the ragged tail of MHC class II-presented peptides of the measles virus fusion protein

Cellular misfolded proteins rescued from degradation by MHC class II molecules are possible targets for autoimmune diseases

A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins

Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes

Upregulation of MHC class II, interferon‐α and interferon‐γ receptor protein expression in HIV‐associated nephropathy

Invariant chains with the class II binding site replaced by a sequence from influenza virus matrix protein constrain low-affinity sequences to MHC II presentation

Fibronectin-binding protein I of Streptococcus pyogenes promotes T cell-independent proliferation of murine B lymphocytes and enhances the expression of MHC class II molecules on antigen-presenting cells.


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Any of a class of histocompatibility proteins encoded by the major histocompatibility complex whose expression is restricted to certain immune cells, in particular B cells, macrophages, other antigen-presenting cells, epithelial cells of the thymus, and (in humans) activated T cells. These proteins bind antigenic peptide fragments derived from pathogens or toxins that have been taken in and degraded by macrophages or B cells and held in vesicles within the cell. The class II proteins then migrate to the cell surface, where they are recognized by receptors of CD4-bearing T cells (i.e. helper T cells), which in turn activate the presenting cell to kill its intracellular pathogens (in the case of macrophages) or to secrete antibodies to neutralize extracellular bacteria or circulating toxins (in the case of B cells). Class II proteins consist of an α chain and a β chain and have a peptide-binding site that is open at both ends and can accommodate longer peptides than MHC class I molecules.

Subjects: Biological Sciences.

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