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The role of microcystins in heavy cyanobacterial bloom formation

The role of microcystins in heavy cyanobacterial bloom formation

Dynamics of microcystin-producing and non-microcystin-producing Microcystis populations is correlated with nitrate concentration in a Japanese lake

Permeabilising effects of sub-inhibitory concentrations of microcystin on the growth of Escherichia coli

Variability of the microcystin synthetase gene cluster in the genus Planktothrix (Oscillatoriales, Cyanobacteria)

Co-occurrence of microcystin and microginin congeners in Brazilian strains of Microcystis sp.

Amino acid availability determines the ratio of microcystin variants in the cyanobacterium Planktothrix agardhii

Microcystin-producing blooms of Anabaenopsis arnoldi in a potable mountain lake in Saudi Arabia

Isolation of a Poterioochromonas capable of feeding on Microcystis aeruginosa and degrading microcystin-LR

Removal of microcystin-LR by strains of metabolically active probiotic bacteria

The presence of the cyanobacterial toxin microcystin in black band disease of corals

Immuno-crossreactivity and toxicity assessment of conjugation products of the cyanobacterial toxin, microcystin-LR

Probabilistic ecological hazard assessment of microcystin-LR allelopathy to Prymnesium parvum

Growth and survival responses of a tropical Daphnia (Daphnia lumholtzi) to cell-bound microcystins

Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade

Microcystins do not necessarily lower the sensitivity of Microcystis aeruginosa to tannic acid

Transmembrane Transport of Microcystin to Danio rerio Zygotes: Insights into the Developmental Toxicity of Environmental Contaminants

Microcystin Congener– and Concentration-Dependent Induction of Murine Neuron Apoptosis and Neurite Degeneration


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Cyanobacterial toxins that are important environmental hazards. They are cyclic heptapeptides containing an unusual hydrophobic amino acid, 3-amino-9-methoxy-10-phenyl-2,6,8-trimethyl-deca-4,6-dienoic acid (ADDA), which is important for their activity. They are potent inhibitors of protein phosphatases, acting at the same site as okadaic acid. Microcystin MC-LR is the most studied and is hepatotoxic and probably carcinogenic. Other cyanobacterial toxins include anatoxins, cylindrospermopsin, domoic acid, and nodularins.

Subjects: Medicine and Health.

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