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A protein complex both necessary and sufficient for processing long primary miRNAs (pri-miRNAs) to the intermediate 60–70-nt precursor miRNAs (pre-miRNAs). It comprises drosha and the double-stranded RNA-binding protein DGCR8 (product of the di George's syndrome critical region 8 gene). The pre-miRNAs are cleaved by another RNase III (dicer) to generate mature miRNAs.

Subjects: Medicine and Health.

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