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One of a small subfamily of thrombospondin type I proteins, the other member being spondin-1 (F-spondin). Like F-spondin, mindin is involved in axonal guidance in the developing brain. Mindin-deficient mice exhibit defective inflammatory and immune responses probably because mindin is a ligand for neutrophil and macrophage integrins and binding via mindin regulates the expression of rho GTPases in dendritic cells.

Subjects: Medicine and Health.

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