A conserved family of proteins (MCM proteins) involved in the initiation and elongation of DNA replication forks in archaea and eukaryotes. The eukaryotic MCM2–7 complex is a heterohexameric helicase, with six related subunits, that assembles at the DNA replication fork. Various MCMs are phosphorylated during the cell cycle, at least in part by cyclin-dependent kinases. MCM-2, like Ki-67, is often used as a marker for grading tumours and MCM-7 is up-regulated in a variety of tumours including neuroblastoma, prostate, cervical, and hypopharyngeal carcinomas.
Subjects: Chemistry — Medicine and Health.