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MLL


'MLL' can also refer to...

MLL

MLL [Airline]

MLL [Airport Code]

Environmental and Genetic Susceptibility to MLL-Defined Infant Leukemia

Dietary flavonoids induce MLL translocations in primary human CD34+ cells

5′ MLL Gene Deletion in a Case with Childhood Acute Lymphoblastic Leukemia

MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters

Cytogenetic and molecular analysis of MLL rearrangements in acute lymphoblastic leukaemia survivors

MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells

Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells

O-GlcNAcylation of MLL5β is essential for MLL5β–AP-1 transcription complex assembly at the HPV16/18-long control region

DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis

The mll6786 gene encodes a repressor protein controlling the degradation pathway for vitamin B6 in Mesorhizobium loti

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

A distinct set of long non-coding RNAs in childhood MLL-rearranged acute lymphoblastic leukemia: biology and epigenetic target

Mechanisms of MLL gene rearrangement: site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context

Chlorpyrifos Induces MLL Translocations Through Caspase 3-Dependent Genomic Instability and Topoisomerase II Inhibition in Human Fetal Liver Hematopoietic Stem Cells

An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes

 

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A gene (myeloid/lymphoid leukaemia gene, mixed lineage leukaemia gene) homologous to the Drosophila gene trithorax, encoding a DNA-binding protein (3910 aa) that methylates histone H3 and positively regulates the expression of target genes, including many homeobox (HOX) genes. It is frequently translocated in leukaemias. MLL is cleaved by taspase-1 to produce fragments that heterodimerize to stabilize the complex and define its intranuclear destination.

Subjects: Medicine and Health.


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