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Moloney murine leukaemia virus


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A virus of mice producing lymphocytic leukemia that can be transmitted from an infected mother to her newborn progeny through her milk. The virus integrates into several locations in the mouse genome, and there is an integration site on human chromosome 5p14. MoMLV is commonly used for gene transfer protocols. First, the viral genes that are required for the production of replication-competent viruses are replaced with those genes that are desired to be transferred. Once the virus is administered, it binds to the host cells and is internalized, and the genes provided by the vector are then integrated randomly into the host chromosomes. Transfers are efficient and the integrations are stable. See Chronology, 1983, Mann, Mulligan, and Baltimore; gene therapy, proto-oncogene, retrovirus, virus.

Subjects: Genetics and Genomics.


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