One of the HSP70 family of proteins (75-kD glucose regulated protein, GRP75). Mortal fibroblasts (i.e. those with a finite division potential) have MOT-1 (679 aa) uniformly distributed in the cytoplasm, immortalized fibroblasts have MOT-2 in a juxtanuclear concentration. Interacts with p53 and promotes its dissociation from centrosomes. The gene is assigned to 5q31.1, the locus of a putative tumour suppressor gene involved in myeloid malignancies.
Subjects: Chemistry — Medicine and Health.