MSH genes

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MSH genes

MSH2 gene

MSH2 gene

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6

Regulation of plant MSH2 and MSH6 genes in the UV-B-induced DNA damage response

1717PThe correlation between MMR gene expression MSH2/MSH6 and VEGF A/VEGF B in gastro-esophageal cancer

Spatiotemporal activity of the mshA gene system in Shewanella oneidensis MR-1 biofilms

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

A homozygous donor splice-site mutation in the meiotic gene MSH4 causes primary ovarian insufficiency

Mismatch Repair Genes hMLH1 and hMSH2 and Colorectal Cancer: A HuGE Review

IVS10+12A>G polymorphism in hMSH2 gene associated with prognosis for patients with colorectal cancer

The Novel Germline Mutation of hMSH2 Gene in a Case of a Colon Cancer Patient Without Family History

Pathogenicity of A600V Variant in Exon 12 of the MSH2 Gene Detected in a Japanese Kindred with Lynch Syndrome

The mshA gene encoding the glycosyltransferase of mycothiol biosynthesis is essential in Mycobacterium tuberculosis Erdman

Mismatch repair gene Msh2 modifies the timing of early disease in Hdh Q111 striatum

Reduced host cell reactivation of oxidative DNA damage in human cells deficient in the mismatch repair gene hMSH2

Germline Mutations of hMLH1 and hMSH2 Genes in Korean Hereditary Nonpolyposis Colorectal Cancer

The Novel Germline Mutation of hMSH2 Gene in a Case of a Hereditary Non-polyposis Colorectal Cancer (HNPCC) Patient Who Meets the Revised Amsterdam Criteria

Point Mutations of Ornithine Decarboxylase Gene are an Infrequent Event in Colorectal Cancer but a Missense Mutation was Found in a Replication Error Positive Patient with hMSH2 Germline Mutation


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A multigene family that encodes proteins involved in mismatch repair. They are the human homologues of the MutS genes in S. cerevisiae, which are themselves homologues of the E. coli MutHLS mismatch repair system that involves the MutH, MutL, MutS, and MutU genes. The protein products of the human genes are MSH2, 3, 4, 5, and GTBP (MSH6). Defects in mismatch repair may arise by mutation in these genes or through imbalance in the expression of some relative to others. Mutations in the MSH2 gene result in hereditary nonpolyposis colorectal cancer-1 and an MSH3 frameshift mutation has been observed in an endometrial carcinoma. MSH4–MSH5 heterodimers bind uniquely to Holliday junctions. MLH1, PMS1 (MLH2), and PMS2 (MLH4) are homologues of the E. coliMutL gene and the yeast PMS (postmeiotic segregation increased-1 and -2) genes respectively.

Subjects: Medicine and Health.

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