A serine/threonine kinase (mammalian/molecular target of rapamycin, 2549 aa), one of the phosphoinositide 3-kinase related kinase (PIKK) family, an important modulator of the size of proliferating cells. The target of rapamycin proteins (TOR1, TOR2) in Saccharomyces cerevisiae regulate growth in a rapamycin-sensitive manner and TOR2 regulates polarization of the actin cytoskeleton. The activity of mTOR is regulated by rheb, a Ras-like small GTPase, in response to growth factor stimulation and nutrient availability. The TOR complex 1 (TORC1) contains mTOR1 or mTOR2, raptor and LST8 and binds FKBP-rapamycin; whereas TORC2, which contains mTOR2, rictor, and LST8 does not. TORC2 disruption causes an actin defect.
Subjects: Medicine and Health — Chemistry.