multiple risk factor intervention trial

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Known by its acronym, this large randomized trial of preventive interventions initially was thought to demonstrate the inadequacy of preventive interventions, such as cholesterol-lowering regimens, because death rates were not significantly different between the groups with and without intervention. However, more detailed analysis revealed that apparent similarity of intervention and control groups was due, in part at least, to contamination of the control group by publicized intervention methods that many adopted, although it was not meant to be part of their regimen; and that intervention did significantly reduce death rates from coronary heart disease, but the death rates due to violent causes, such as traffic crashes and suicide, were significantly elevated in the intervention group, raising the possibility that lower cholesterol levels were associated with adverse modification of mood. A brief description and formalities for access to data sets from the MRFIT studies are at http://www.nhlbi.nih.gov/resources/deca/descriptions/mrfit.htm.

Subjects: Public Health and Epidemiology.

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