Overview

mycolactone


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A family of toxins produced by Mycobacterium ulcerans; strains from different geographic areas produce distinct patterns of mycolactone congeners. Mycolactone has significant immunosuppressive effects and inhibits production of macrophage inflammatory protein (MIP-1α), MIP-1β, RANTES, interferon-γ-inducible protein 10, and monocyte chemoattractant protein 1, but not IL-12, TNFα, or IL-6. See Buruli ulcer.

Subjects: Medicine and Health.


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