myelin proteolipid protein

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The primary constituent of myelin in the central nervous system. There are two isofoms, PLP and DM20, produced by alternative splicing; both are very hydrophobic integral membrane proteins, tetraspanins, with two extracellar loops and one intracellular loop. Mutation in the PLP gene leads to X-linked hereditary spastic paraplegia type 2 (SPG2) and to the X-linked dysmyelinating disorder of the central nervous system, Pelizaeus–Merzbacher disease.

Subjects: Medicine and Health.

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