A neoplastic plasma cell. In multiple myeloma the proliferating plasma cells dominate the marrow, leading to immune deficiency and often destruction of surrounding bone. Various molecular events can cause the disorder, including dysregulation of oncogenes by translocations to the IgH locus, mutations in genes encoding cyclin D1 and fibroblast growth factor receptor-3. (See also multiple myeloma oncogene-1.) Myeloma cells are monoclonal and therefore secrete a single type of immunoglobulin, a characteristic exploited in the production of monoclonal antibodies by hybridoma cells; see Bence Jones protein.
Subjects: Medicine and Health.