myeloproliferative disease

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Any disease caused by the uncontrolled proliferation of blood cells produced in the bone marrow. Leukemias result from proliferating lymphocytes. Lymphomas also contain proliferating lymphocytes, but in this case the sources are lymph nodes. Granulocytes, monocytes, and megakaryocytes (all of which see) are the sources of myeloid leukemias. The designation “acute” indicates that the cancer cells remain immature, divide rapidly, and are destined to overwhelm the body; whereas the “chronic” term is used for cells that divide less frequently and mature enough to perform some of their normal functions. See Abelson murine leukemia virus, acute myeloid leukemia 1 gene, Burkitt lymphoma, Philadelphia (Ph1) chromosome, polycythemia.

Subjects: Genetics and Genomics.

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