Overview

myosin-binding proteins


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hypertrophic cardiomyopathy

obscurin

sarcomere

 

'myosin-binding proteins' can also refer to...

myosin-binding proteins

myosin‐binding C protein

PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice

Impairment of the ubiquitin–proteasome system by truncated cardiac myosin binding protein C mutants

Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1

A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy

50Cardiac myosin-binding protein C in the pre-hospital setting: identifying the high-risk patient

Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice

114 Alterations in sarcomeric protein expression, phosphorylation and contractile function in hypertrophic cardiomyopathy patients carrying a founder mutation in myosin binding protein C

The role of cardiac myosin binding protein-C as a regulator of myofilament Ca2+ sensitivity

P679Ultrastructural and electron tomography analyses of cardiac muscle: normal muscle compared to presence and absence of myosin binding protein C-phosphorylation

The yield of risk stratification for sudden cardiac death in hypertrophic cardiomyopathy myosin-binding protein C gene mutation carriers: focus on predictive screening

Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies

Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9

117 Use of drosophila to approach the in vivo function of human cardiac myosin binding protein C

 

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A family of muscle proteins that bind myosin (MyBPs). The most abundant type is MyBPC, which is transversely arrayed in the cross-bridge-bearing (C region) of the A band of the sarcomere in a fixed molar ratio with myosin heavy chains. MyBPC2 (1142 aa) is found in fast skeletal muscle, MyBPC1 in slow muscle. MyBPC3, the cardiac isoform, is expressed exclusively in heart muscle. Protein kinase A-mediated (PKA) phosphorylation of MyBPC3 accelerates the kinetics of cross-bridge cycling and regulates myocyte power output. Mutations are associated with ~15% of cases of familial hypertrophic cardiomyopathy. See obscurin. Myosin-binding protein H (MyBPH, 52 kDa) is found in skeletal muscle in a specific pattern.

Subjects: Medicine and Health — Chemistry.

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Reference entries
myosin‐binding C protein
in Oxford Dictionary of Biochemistry and Molecular Biology

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myosin-binding proteins
in A Dictionary of Biomedicine

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