myosin heavy chain

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'myosin heavy chain' can also refer to...

myosin heavy chain

myosin heavy chain

myosin‐heavy‐chain kinase

myosin-heavy-chain kinase

Evolution of Sarcomeric Myosin Heavy Chain Genes: Evidence from Fish

Calcium-mediated regulation of recombinant hybrids of full-length Physarum myosin heavy chain with Physarum/scallop myosin light chains

Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb)

Two novel mutations in the β-myosin heavy chain gene associated with dilated cardiomyopathy

Myosin heavy chain-9-related disorders (MYH9-RD): a case report

Evolutionary Implications of Three Novel Members of the Human Sarcomeric Myosin Heavy Chain Gene Family

Commentary: Nuclear Receptors and Myosin Heavy Chain Gene Expression in the Aged Myocardium

Myosin Heavy Chain Plasticity in Aging Skeletal Muscle With Aerobic Exercise Training

Differential expression of myosin heavy chain isoforms in the masticatory muscles of dystrophin-deficient mice

Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene

Cleavage of Nonmuscle Myosin Heavy Chain-A during Apoptosis in Human Jurkat T Cells

19 Alpha-myosin heavy chain mutations associated with dilated and hypertrophic cardiomyopathy

22 Low prevalence of beta myosin heavy chain gene mutations in Hungarian patients with hypertrophic cardiomyopathy

P1544Increase of serum myosin heavy chain-alpha after triathlon demonstrates heart muscle cell death

The structural effects of mutations can aid in differential phenotype prediction of beta-myosin heavy chain (Myosin-7) missense variants


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The large subunit of myosin (~2000 aa) that has the ATPase activity. The head region undergoes conformational change during the actin attachment/detachment cycle, each cycle involving hydrolysis of one ATP molecule, and it is this conformational change that converts energy into movement. In conventional filament-forming myosins (type II myosin) the head is attached via a hinge region to a tail domain that interacts laterally with other myosin tails to form the backbone of the thick filament In the nonmuscle myosins, the tail may attach to ‘cargo’ vesicles. In skeletal muscle there are seven heavy chain isoforms, two developmental, three in adult skeletal muscle, one also expressed in cardiac muscle, one expressed primarily in extrinsic eye muscles. Mutations in the gene for myosin heavy chain 9 lead to the May–Heggelin anomaly. Heavy meromyosin is a subfragment of the heavy chain of myosin II. See also myosin light chains.

Subjects: Medicine and Health.

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