Overview

myopodin


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An actin bundling protein (three isoforms, 1093, 1109, and 1261 aa respectively) with a nuclear localization signal that can shuttle between nucleus and cytoplasm. Myopodin can become hypermethylated, especially in some bladder cancers, and the hypermethylation apparently prevents it from activating gene expression. Myopodin is a tumour suppressor that inhibits prostate cancer growth and metastasis and has significant homology with synaptopodin.

Subjects: Medicine and Health.


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