Overview

necdin


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A growth suppressor protein (321 aa) that interacts with the nerve growth factor receptor and induces terminal differentiation of postmitotic neurons in the brain. Necdin-like proteins are a family within the MAGE superfamily. Expression of the necdin gene is restricted to the paternal allele (see genomic imprinting), and necdin is one of several genes disrupted in Prader–Willi syndrome.

Subjects: Medicine and Health.


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