Overview

N-end rule


Show Summary Details

Quick Reference

A rule, conserved in pro- and eukaryotes, that holds that the identity of the N-terminal residues of proteins determines the in vivo half-life. N-recognins, a class of E3 ligases (see ubiquitin conjugating enzymes), bind to a destabilizing N-terminal residue of a substrate protein and are involved in ubiquitination and subsequent proteasomal degradation.

Subjects: Medicine and Health.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.