N-end rule

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A rule, conserved in pro- and eukaryotes, that holds that the identity of the N-terminal residues of proteins determines the in vivo half-life. N-recognins, a class of E3 ligases (see ubiquitin conjugating enzymes), bind to a destabilizing N-terminal residue of a substrate protein and are involved in ubiquitination and subsequent proteasomal degradation.

Subjects: Medicine and Health.

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