A family of basic helix–loop–helix transcription factors involved in neuronal differentiation. Neurogenin-1 (237 aa) is required for specification of dopaminergic progenitor cells and inhibits the differentiation of neural stem cells into astrocytes. Neurogenins 2 and 3 (272 aa and 214 aa) control distinct phases of neurogenesis involved in differentiation of different classes of sensory neurons. Mutation in the neurogenin 3 gene is associated with congenital malabsorptive diarrhoea.
Subjects: Medicine and Health.