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NFAT


'NFAT' can also refer to...

NFAT

NF‐AT

NFAT signalling and the differentiation of coronary smooth muscle cells

Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure

Calcineurin–NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes

Heart block in mice overexpressing calcineurin but not NF-AT3

Calcineurin-NFAT activation and DSCR-1 auto-inhibitory loop: how is homoeostasis regulated?

Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT

Syndecan-4 signalling inhibits apoptosis and controls NFAT activity during myocardial damage and remodelling

Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB

54 Prohibition of calcineurin/importin-interaction disrupts calcineurin/NFAT cascade

CagA and NFAT co-operatively participate in the lymphomagenesis of gastric MALT lymphoma

822 Dual-specificity tyrosine phosphorylation-regulated kinase 1A is a NFAT kinase mediating negative feedback on Calcineurin/NFAT signaling in cardiac myocytes

423 Genome wide expression profiling of NFAT transcriptional activity in a ventricular muscle cell line identifies GATA4 as an NFAT target gene in a feedforward mechanism driving cardiomyocyte hypertrophy

The MKK6–p38 MAPK pathway prolongs the cardiac contractile calcium transient, downregulates SERCA2, and activates NF-AT

Erratum to Increased regulatory activity of the calcinerum/NFAT pathway in human heart failure [Eur J Heart Fail 2004; 6:3]

Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: Co-operation with Src tyrosine kinase

Interference of antihypertrophic molecules and signaling pathways with the Ca2+–calcineurin–NFAT cascade in cardiac myocytes

 

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A family of transcription factors originally identified as a DNA-binding complex activated when T cells are stimulated by antigen (nuclear factor of activated T cells) but now known to be involved in regulating gene expression in non-immune tissues including skeletal muscle. The complex consists of several components, including homodimers or heterodimers of fos and jun family proteins, and a pre-existing cytosolic component (NFATP, NFAT1, or NFATC2) that translocates to the nucleus when dephosphorylated by calcineurin, a step that is inhibited by ciclosporin and tacrolimus.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11877454 Abstract of a paper on NFAT in the Journal of Cell Biology (2002).

Subjects: Medicine and Health — Chemistry.


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