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NFAT


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NFAT

NF‐AT

NFAT signalling and the differentiation of coronary smooth muscle cells

Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB

Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure

Calcineurin–NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes

Heart block in mice overexpressing calcineurin but not NF-AT3

54 Prohibition of calcineurin/importin-interaction disrupts calcineurin/NFAT cascade

Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT

Syndecan-4 signalling inhibits apoptosis and controls NFAT activity during myocardial damage and remodelling

Calcineurin-NFAT activation and DSCR-1 auto-inhibitory loop: how is homoeostasis regulated?

822 Dual-specificity tyrosine phosphorylation-regulated kinase 1A is a NFAT kinase mediating negative feedback on Calcineurin/NFAT signaling in cardiac myocytes

423 Genome wide expression profiling of NFAT transcriptional activity in a ventricular muscle cell line identifies GATA4 as an NFAT target gene in a feedforward mechanism driving cardiomyocyte hypertrophy

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons

Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signalling pathway

Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression

NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone

Analysis of NFAT-regulated gene expression in vivo: a novel perspective for optimal individualized doses of calcineurin inhibitors

 

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A family of transcription factors originally identified as a DNA-binding complex activated when T cells are stimulated by antigen (nuclear factor of activated T cells) but now known to be involved in regulating gene expression in non-immune tissues including skeletal muscle. The complex consists of several components, including homodimers or heterodimers of fos and jun family proteins, and a pre-existing cytosolic component (NFATP, NFAT1, or NFATC2) that translocates to the nucleus when dephosphorylated by calcineurin, a step that is inhibited by ciclosporin and tacrolimus.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11877454 Abstract of a paper on NFAT in the Journal of Cell Biology (2002).

Subjects: Medicine and Health — Chemistry.


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