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A MAP kinase kinase kinase (NFκB-inducing kinase, MAP3K14, 947 aa) that activates the CD28 responsive element (CD28RE) of the IL-2 promoter and is downstream of the TNFα, IL-1, and CD95 signalling cascades that activate NFκB. A NIK and IκB-binding protein (NIBP) plays a role in the neuronal NFκB signalling pathway.
From: NIK in A Dictionary of Biomedicine »
Subjects: Medicine and Health.
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