A receptor on synapses that binds the neurotransmitter glutamate and also binds its agonist NMDA (N-methyl-D-aspartate). This receptor is involved in learning, memory, mood, and cognition; its overactivity is associated with chronic pain. NMDA-receptorantagonists (e.g. amantadine, memantine hydrochloride, riluzole) are used in the treatment of (among other conditions) epilepsy, Alzheimer’s disease, and chronic pain syndromes.
Subjects: Medicine and Health.