A signalling molecule involved in induction of mesoderm and endoderm and a member of the TGFβ family. In mice nodal is expressed during mouse gastrulation in a left-sided pattern and appears to be important in development of left–right asymmetry. A mutation in nodal has been observed in a female with situs ambiguus. See cerberus; ZIC3. Nodal modulators (NOMO1, 1222 aa; NOMO2, 1267 aa; and NOMO3, 1222 aa ) apparently down-regulate nodal signalling and are transmembrane proteins that interact with nicalin.
Subjects: Medicine and Health.