An embryonic inducing factor (232 aa) highly homologous to the dorsalizing factor produced by the Spemann's organizer region of the amphibian embryo. Noggin modulates bone morphogenetic protein (BMP) signalling by binding and inactivating BMP and is essential for normal skeletal development. Mutations are associated with bone or joint fusion abnormalities (synostoses). Noggin expression overlaps with that of chordin.
Subjects: Medicine and Health.